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Chandana, ©2008 Todd Caldecott

Botanical name: Santalum album, Santalaceae

Common names: Chandana ('gladdening') (S); Sandal (H), Chandanam (T), Sandalwood (E), Tan xiang (C)

Part used: Dried heartwood, essential oil.

Botany: Chandana is a medium-sized evergreen parasitic tree with slender drooping branches that when mature attains a height of up to 18 meters.  The rough bark is dark grey to brownish black with short vertical cracks, and the highly scented heartwood is yellowish-brown in colour when fresh and becoming dark reddish brown with oxidation. The leaves are simple, opposite, elliptic-lanceolate and glabrous.  The flowers are brownish or reddish purple borne in axillary paniculate cymes, giving rise to globose fruits drupes.  Chandana is found in the dry deciduous forests of south India on stony but fertile soil, up to 1200 meters in elevation.  Chandana and allied species are scattered widely from the Malay Archipelago  to Australia and the Pacific islands including Hawaii.  In India only wild mature specimens of Chandana between 30 and 50 years are considered suitable for harvesting, and this relatively slow growth complexed with a consistently high demand for this product, as well as illegal poaching, forest fires and disease, has made it a threatened species.  India currently does not allow the export of any S. album timber.  A similar species native to Australia identified as S. spicatum is currently being used as a substitute for S. album (Evans 1989, Hamilton & Conrad 1990, Kirtikar & Basu 1935, Warrier et al 1996).

Dravyguna:
Rasa: tikta
Vipaka: laghu
Virya: shita, ruksha
Karma: Pittakaphahara, medhyam, balya, mutravishodhana, hrdaya, chedana, dahaprashamana, raktasthambhana, jvaraghna, kushtaghna
Prabhava: Chandana is said to be ahladana ('gives happiness') (Srikanthamurthy 2001, 208; Dash 1991, 32; Frawley and Lad 1986, 213; Nadkarni 1954, 1099; Warrier et al 1996, 57)

Constituents: The heartwood of Chandana contains an essential oil called sandalwood oil, 90% of which are the sesquiterpene alcohols Α and Β-santalol, and 6% sesquiterpene hydrocarbons including Α and Β-santalenes, epi-Β-santalene, and Α and Β-curcumenes.  The a and b-santalols are responsible for the characteristic odour and colour of sandalwood oil.  Other constituents in the essential oil include dihydro-Β-agarofuran, santene, teresantol, borneol, teresantalic acid, santalone, santanol and trcyclo-ekasantalal. The bark contains tannins, fatty acids and a waxy material.  The essential oil of S. spicatum is said to contain a very similar range of constituents as S. album, as well as the sesquiterpene furan dendrolasin that has a sweet, lemongrass fragrance (Yoganarasimhan 2000, 481; Evans 1989, 474; Duke 1985, 426; Walker 1968).

Medical research:
Antiviral:The essential oil of Santalum album was found to inhibit the replication of Herpes simplex viruses-1 and ­2.  This effect was dose-dependent and more pronounced against HSV-1 (Benencia and Courreges. 1999).
Chemprotective: The chemopreventative effect of Α-santalol isolated from sandalwood oil by distillation was assessed in carcinogenesis initiated by 7,12-dimethylbenz(a)anthracene and promoted with 12-O-tetradecanoylphorbol-13-acetate (TPA) in female mice.  During the promotion phase Α-santalol treatment delayed papilloma development by two weeks in both strains of mice, significantly inhibiting ornithine decarboxylase (ODC) activity and (3)H-thymidine incorporation in epidermal DNA induced by TPA (Dwivedi et al 2003).  The essential oil of Santalum album displayed chemoprotective effects on 7,12-dimethylbenz(a)anthracene-(DMBA)-initiated and 12-O-tetradecanoyl phorbol-13-acetate(TPA)-promoted skin papillomas, and TPA-induced ornithine decarboxylase (ODC) activity in mice.  Treatment with Santalum album oil significantly decreased papilloma incidence by 67%, multiplicity by 96%, and TPA-induced ODC activity by 70% (Dwivedi and Abu-Ghazaleh. 1997). The essential oil of Santalum album was found to enhance glutathione S-transferase (GST) activity and acid soluble sulphydryl (SH) levels in the liver of adult male mice, suggesting a possible chemopreventive action (Banerjee et al. 1993).
Hypotensive: Santalum ellipticum was found to have a hypotensive activity (Bourke et al 1973).
Hepatic:Santalbic acid extracted from Santalum acuminatum was fed to rats for 10 and 20 days such that it made up 12.6% of total energy content in a semi-synthetic diet.  Santalbic acid was found in the lipids of plasma, adipose tissue, skeletal muscle, kidney, heart and liver but not in brain.  Hepatic microsomal cytochrome P-450 activity in animals fed santalbic for 20 days was significantly higher than controls (Jones et al 1994).

Toxicity: Possible cytochrome p-450 inducement in high doses long term (Jones et al 1994).  The essential oil reported to have a "baneful effect upon the kidneys" in larger doses, taken internally (Nadkarni 1954, 1102).

Indications: Gastric irritability, dysentery, biliousness, jaundice, cough, bronchitis, fever, inflammatory skin diseases, herpes, skin cancer, poisoning, thirst, hemorrhage, burning sensations, cystitis, menorrhagia, leucorrhea, headache, memory loss, psychosis, depression, cardiac debility, palpitations, arrhythmia.

Contraindications: Renal disease; Vatakopa; concurrent usage with pharmaceuticals; beware of common adulterants to the oil, such as castor and cedar wood oil.

Medicinal uses: Chandana has long been esteemed in India as not only a useful medicine, but as an important construction material that is highly resistant to decay, and as an important fragrance in Hindu ceremonies, often applied to the forehead by devout Hindus as a tilak to pacify the doshas of the mind.  To this end the Chakradatta mentions Chandanadi lepa in the treatment of headache, comprised of equal parts powders of Chandana, Ushira, Madhuka (Glycyrrhiza glabra), Bala, Vyaghranakha (Capparis zeylanica) and Nilotpala (Monochoria hastata), mixed with milk, prepared as a paste and applied to the head (Sharma 2002, 562).  Several texts including the Charaka samhita, Chakradatta and Sharngadhara samhita mention a complex polyherbal medicated oil that contains Chandana as the chief ingredient called Chandanadya taila, taken internally and applied topically in the treatment of spiritual possession, epilepsy, mental disorders, hemorrhage and consumptive conditions (Sharma 2002, 144; Srikanthamurthy 1984, 135).  On a more mundane level, Chandana is specific to Paittic disorders, the ground powder applied topically as a paste made with cool water or milk for inflammatory skin conditions such as herpes, scabies, pruritis, prickly heat, and insect bites, and internally as an emulsion in the treatment of gastric irritability, dysentery, thirst, and heat stroke.  In mild tachycardia (i.e. "tobacco heart") Chandana is stated to have a calming nervine effect, slowing heart rate and promoting contentment and relaxation (Nadkarni 1954, 1102).  Bensky and Gamble mention that Chandana is used with the Chinese herbs Dan shen (Salvia miltorrhiza) and Xi xin (Asarum sieboldii) for angina (1986, 240).  The essential oil of Chandana is a useful remedy in afflictions of the urinary tract, such as cystitis, gonorrhea and pyelitis, and can be used in similar dosages for irritating coughs and bronchitis.  The Eclectic physicians Felter and Lloyd state that the oil is specific to "…subacute and chronic affections of mucous tissues, particularly gonorrhoea after the active symptoms have been mitigated" (1893).  An emulsion of the wood mixed with sugar, honey and rice is used to check gastric irritability (Nadkarni 1954, 1101).  When mixed with zinc oxide ointment (10%, v/v), the essential oil is a useful adjunct in the treatment of herpetic lesions, reapplied every few hours over a period of days until the inflammation ceases.  Owing to its astringent and cooling qualities, Chandana is a useful hemostatic and a specific to a group of diseases called rakta pitta, all of which are characterized by hemorrhage, as well as daha, or Œburning sensations.¹  To this end Chandana is taken both internally and applied topically, in the latter case either as a paste mixed with cool milk or decocted and then cooled as a bath.  Due to its drying (ruksha) properties a decoction of Chandana is also recommended by the Ashtanga Hrdaya as dravya for vasanta rtu charya (spring regimen) to relieve excess Kapha (Srikanthamurthy 1994, 37).

Dosage
Churnam: 3-5 g b.i.d.-t.i.d.
Kvatha: 1:4, 30-90 mL b.i.d.-t.i.d.
Tincture: 1:5, 50% alcohol, 1-4 mL b.i.d.-t.i.d.
Essential oil: 5-10 gtt (encapsulated, suspended in Acacia gumpowder or similar) b.i.d.-t.i.d.

References:
Banerjee, S et al. 1993. Modulatory influence of sandalwood oil on mouse hepatic glutathione S-transferase activity and acid soluble sulphydryl level. Cancer Lett. Feb;68(2-3):105-9
Benencia, F. and M.C. Courreges. 1999. Antiviral activity of sandalwood oil against herpes simplex viruses-1 and -2. Phytomedicine. May;6(2):119-23
Bensky, D. and A. Gamble. 1993. Chinese Herbal Medicine Materia Medica. Revised edition. Seattle: Eastland Press.
Bourke, E.L. et al. 1973. A hypotensive agent in Santalum ellipticum. Planta Med. Mar;23(2):110-4
Dash, Bhagwan.  1991.  Materia Medica of Ayurveda.  New Delhi: B. Jain Publishers.
Duke, JA. 1985. Handbook of Medicinal Herbs. Boca Raton, FLA: CRC Press
Evans, WC. 1989. Trease and Evan¹s Pharmacognosy. London: Bailliere-Tindall
Felter HW and JU Lloyd. 1893. King¹s American Dispensatory. Online version available from: http://www.ibiblio.org/herbmed/eclectic/kings/main.html
Frawley, David and Vasant Lad. 1986. The Yoga Of Herbs: An Ayurvedic Guide to Herbal Medicine.  Santa Fe: Lotus Press.
Dwivedi C, Guan X, Harmsen WL, Voss AL, Goetz-Parten DE, Koopman EM, Johnson KM, Valluri HB, Matthees DP. 2003. Chemopreventive Effects of alpha-Santalol on Skin Tumor Development in CD-1 and SENCAR Mice. Cancer Epidemiol Biomarkers Prev. Feb;12(2):151-6
Dwivedi, C and A. Abu-Ghazaleh. 1997. Chemopreventive effects of sandalwood oil on skin papillomas in mice. Eur J Cancer Prev. Aug;6(4):399-401
Jones G.P. et al. 1994. Effect of feeding quandong (Santalum acuminatum) oil to rats on tissue lipids, hepatic cytochrome P-450 and tissue histology. Food Chem Toxicol. Jun;32(6):521-5
Kirtikar KR and BD Basu. 1935. Indian Medicinal Plants. Reprint. Delhi: Periodical Experts.
Nadkarni, Dr. K.M.  1954.  The Indian Materia Medica, with Ayurvedic, Unani and Home Remedies.  Revised and enlarged by A.K. Nadkarni. 1954. Reprint. Bombay:  Bombay Popular Prakashan PVP.
Sharma, P.V. 2002. Chakradatta. Sanskrit Text with English Translation. Varanasi: Chaukhamba
Srikanthamurthy, K.R. 2001. Bhavaprakasha of Bhavamishra. Vol. 1. Varanasi: Krishnadas Academy
Srikanthamurthy, K.R. 1994. Vagbhata¹s Ashtanga Hrydayam. Vol. 1. Varanasi: Krishnadas Academy
Srikanthamurthy, K.R. 1984. Sharangadhara samhita. Varanasi: Chaukhamba Orientalia
USDA. 1990. Proceedings of the symposium on Sandalwood in the Pacific. April 9-11, 1990, Honolulu, Hawaii
Warrier PK, Nambiar VPK, Ramankutty C. eds. 1996. Indian Medicinal Plants: A Compendium of 500 species. Edited by PK Warrier, VPK Nambiar and C Ramankutty. Vol 5.  Hyderabad: Orient Longman.
Walker. G.T. 1968. Sandalwood Oil, The Chemistry of oil of Sandalwood, Perfum Essent. Oil Rec. 59 778-785

 

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