Fibromyalgia

Fibromyalgia Syndrome (FMS) is a chronic debilitating state of widespread musculoskeletal pain, stiffness, and fatigue. Unlike arthritis, the term “myalgia” refers to muscular pain not joint pain, primarily felt in fibrous tissues, muscles, tendons, ligaments and other “white” connective tissues. Both fibrositis and fibromyalgia are used interchangeably, but the latter term more accurately describes the condition. In order to clarify the condition the American College of Rheumatology developed criteria for diagnosis in 1990. Generally, there must be a history of widespread pain throughout the body, including pain in 11 of 18 tender point sites with a finger pressure of around 4kg. Sites include the suboccipital muscle insertions at the occiput, the lower cervical paraspinals, the trapezius at midpoint of the upper border, the supraspinatus at its origin above medial scapular spine, the 2nd costochondral junction, 2 cm distal to the lateral epicondyle in the forearm, upper outer quadrant of buttock, greater trochanter, and at the knee just proximal to the medial joint line (Wolfe et al 1990).

There is a broad of overlap between the signs and symptoms of both FMS and Chronic Fatigue Syndrome (CFS), and about 70% of patients with FMS meet the CDC criteria for CFS, and two thirds of CFS patients meet the criteria for FMS (Buchwald 1987; Goldenberg 1990; Goldenberg 1990 et al). The most common of FMS symptoms include muscular pain, aching or stiffness (especially in the morning), a worsening of symptoms with cold weather, a history of injury within the year before the symptoms first began, depression, irritable bowel syndrome, headaches, Raynaud's phenomena, anxiety, dry eyes and mouth, osteoarthritis and rheumatoid arthritis (Block 1993; Duna and Wilke 1993; Goldenberg 1993; Rothschild 1991)

Although medical practitioners commonly refer FMS patients to a psychiatrist, research suggests that FMS may be an autoimmune condition. A great deal of evidence suggests that FMS is the result of immune dysfunction. For example, antibodies to cardiolipin , which is often a feature of autoimmune disorders, have been found in FMS patients presenting with neuropathic symptoms (Romano and Homburger 1991).

In another study, researchers reported that an influenza virus infection may be a possible contributory factor to FMS. All patients in this study reported a history of chronic upper respiratory infection, along with associated neurological symptoms prior to the onset of FMS (Tyler and Allen 1997). Abnormal immunity in FMS victims is also evidenced by studies in which biopsies of muscles found edema, elevated numbers of mast cells, and increased fluid content, suggestive of allergy. FMS is seen more often in patients suffering from immune-related disorders such as Sjogren's syndrome, rheumatoid arthritis, Raynaud's phenomenon, and autoimmune thyroiditis (leading to hypothyroidism). In one study, researchers studied 60 patients with systemic lupus erythematosus, 10 of which were classified as positive for fibomylagia, suggesting that patients with SLE are at risk of developing secondary fibromyalgia (Grafe et al 1999).

Sleep deprivation has been found to reproduce the immune system dysfunction seen in FMS. It appears that FMS may be due to non-restorative deep sleep, an alpha EEG sleep anomaly in non-REM sleep, that initiates a series of immune system abnormalities (Moldofsky 1975; Moldofsky 1993; Moldofsky 1995). This type of abnormal sleep causes elevations in certain cytokines such as interleukin-2, found to be elevated in FMS patients (Wallace 1990).

Medical Treatment of Fibromyalgia

The medical treatment of fibromyalgia relies for the most part upon the oral administration of NSAIDs and corticosteroids, as well as the focal administration of anesthetics such as lidocaine. Most often some kind of antidepressant is administered, such as amitryptyline. Unfortunately such antidepressants interfere with the REM sleep so badly needed by FMS patients.  A new therapy that is gaining some acceptance among physicians is prolotherapy. Basically, this procedure involves the injection of an irritant solution into weak or damaged ligaments. The resulting localized inflammatory response enhances fibroblast activity, which can end up making the ligament about 30-40% stronger. A special feature of prolotherapy however is that patient must refrain from using both NSAIDs and corticosteroids as they will interfere with the effectiveness of the treatment by inhibiting the inflammatory/immune response.  

Holistic Treatment of Fibromyalgia

The treatment protocols for FMS should be based similar protocols that are followed for autoimmune disease, often utilizing specific elements of the protocols for Intestinal Permeability and rheumatoid arthritis (called amavata in Ayurveda). Additional useful supplements include mallic acid (1- 3 g daily) taken with magnesium (800-1200 mg), or to bowel tolerance.

Nutmeg (Myristica fragrans) is an exceedingly useful herb to help with the pain at night. It has an antispasmodic and sedative activity with a four to six hour onset. Ideally the patient should grind enough of the whole fruit in a coffee grinder to last for about a week: if left too long the medicinal volatile oils will degrade, and thus, commercial nutmeg powder is to be avoided. The only other way to preserve its medicinal properties is to make a 1:5 tincture of the crushed fruit, with 50% ethyl alcohol. The recommended dose for Nutmeg is 1-10 caps of the freshly powdered dried fruit, or 1-5 mL of the tincture, in the early evening. Other useful nervine and sedative therapies include Jamaican Dogwood (Piscidia erythrina) and California Poppy (Eschscholzia californica). Another potentially helpful agent is 5-HTP (5-hydroxytryptophan), the biologic precursor to serotonin, which may be of special use in patients reliant upon sleeping pills to ensure a good night's sleep (Puttini and Caruso 1992).

Massage therapy is an important aspect to treatment, with particular attention being paid to the trigger points, which may be painful. Useful Ayurvedic medicated oils include Mahanarayana taila and Kottamchukkadi taila. Heat applications are useful, used locally as a heating pad or hot water bottle, or body wide as in an Epsom salt bath. The external use of diluted essential oils such as Lavender, Ginger, Rosemary, Black Pepper, Eucalyptus, Camphor, Juniper and Chamomile can help to enhance the effectiveness of the heat applications. Kelp baths, available in some spas, are made by filling a bath tub with tepid water and fresh kelp, and can provide great relief. Finally, some kind of gentle, physical exercise such as Tai Chi or Yoga should be practiced everyday to stretch the muscles.